1.河南中医药大学中医药科学院 河南省中医方证信号传导重点实验室 河南 450046
2.河南中医药大学研究生院
3.河南省洛阳正骨医院重症医学科
刘燕,女,博士,实验师
# 通信作者:陈玉龙,男,博士,教授,博士生导师,主要研究方向:中医肿瘤方证相关研究,E-mail:cyl72621@163.com
收稿:2020-08-12,
纸质出版:2021-02-28
移动端阅览
刘燕, 吴耀松, 刘俊, 等. 从正邪转化探讨肿瘤病机与治疗[J]. 北京中医药大学学报, 2021,44(2):183-187.
Yan Liu, Yaosong Wu, Jun Liu, et al. Pathogenesis and treatment of tumors from the perspective of "transformation between healthy qi and pathogenic qi"[J]. Journal of Beijing University of traditional Chinese Medicine, 2021, 44(2): 183-187.
刘燕, 吴耀松, 刘俊, 等. 从正邪转化探讨肿瘤病机与治疗[J]. 北京中医药大学学报, 2021,44(2):183-187. DOI: 10.3969/j.issn.1006-2157.2021.02.015.
Yan Liu, Yaosong Wu, Jun Liu, et al. Pathogenesis and treatment of tumors from the perspective of "transformation between healthy qi and pathogenic qi"[J]. Journal of Beijing University of traditional Chinese Medicine, 2021, 44(2): 183-187. DOI: 10.3969/j.issn.1006-2157.2021.02.015.
通过阅读文献,对正邪相互转化的关系进行探讨,并在古今文献报道基础上指出肿瘤发生的关键因素——“恶气”是由正气失和化邪,邪气伏而化恶产生的。恶气弥散、熏蒸、充斥于机体组织内部,为肿瘤的形成提供了温床,与现代医学肿瘤微环境的概念有着异曲同工之妙。治疗当和其不和、疏利气机,使邪气复正、恶气消散。基于正邪转化角度阐释恶气产生机制,可更好地解释肿瘤的中医病因病机,指导临床治疗。将恶气理论与肿瘤微环境相接轨,可从细胞和分子水平上揭示恶气的内涵,为中医理论现代化研究提供思路和借鉴。
Based on an analysis of "transformation between healthy qi and pathogenic qi" discussed in literatures
this paper points out that "e qi" (evil qi) seems to be the key factor of tumor occurrence. "E qi" is transformed from "pathogenic qi" lurked within the body
which is transformed from disharmonious healthy qi. "E qi" diffuses
fumigates
and fills the body
providing a 'hotbed’ for tumor formation
which is similar to the concept of "tumor microenvironment" in modern medicine. In treatment of tumors
harmonize the discordant and promote qi movement
thus turning the pathogenic qi back to healthy qi to dissipate the 'e qi’. Through interpreting the mechanism of 'e qi’ based on the transformation of healthy qi and pathogenic qi
we can better explain the etiology and pathogenesis of tumors in TCM and guide clinical treatment. By correlating the theory of 'e qi’ with the tumor microenvironment
we hope to reveal the connotation of 'e qi’ in the cellular and molecular level
and provide references for the modernization of TCM theories.
王圆圆 , 陈柯羽 , 张青 . 基于“正邪学说”的肿瘤标本理论及临床应用 [J]. 中医杂志 , 2013 , 54 ( 21 ): 1808 - 1811 .
YY Wang , KY Chen , Q Zhang . Tumor specimen theory based on “theory of vital qi and pathogenic qi” and its clinical application [J]. Journal of Traditional Chinese Medicine , 2013 , 54 ( 21 ): 1808 - 1811 .
刘清华 , 王璐璐 . 基于中医正邪学说关系浅析肿瘤免疫治疗的理论探讨 [J]. 中医肿瘤学杂志 , 2019 , 1 ( 1 ): 8 - 11 .
QH Liu , LL Wang . A theoretical discussion on tumor immunotherapy based on the relationship between vital qi and pathogenic qi [J]. Journal of Oncology in Chinese Medicine , 2019 1,1 ( 1 ): 8 - 11 .
石翎笙 , 贺娟 . 《黄帝内经》“正气”概念内涵辨析 [J]. 北京中医药大学学报 , 2020 , 43 ( 6 ): 469 - 474 .
LS Shi , J He . Analysis of the concept of “Zhengqi” in Huangdi Neijing [J]. Journal of Beijing University of Traditional Chinese Medicine , 2020 , 43 ( 6 ): 469 - 474 .
烟建华 , 张俐敏 . 《黄帝内经》“邪”概念内涵的学术解读 [J]. 中华中医药杂志 , 2007 , 22 ( 8 ): 507 - 510 .
JH Yan , LM Zhang . Academic connotation of “pathogenic factors” in Huangdi Neijing [J]. China Journal of Traditional Chinese Medicine and Pharmacy , 2007 , 22 ( 8 ): 507 - 510 .
梁艳 , 陈子杰 , 王慧如 , 等 . 论《黄帝内经》治疗和养生中的正邪观 [J]. 吉林中医药 , 2017 , 37 ( 11 ): 1089 - 1091 .
Y Liang , ZJ Chen , HR Wang , et al . Health qi and pathogenic qi in the treatment and health preservation of Internal Classic [J]. Jilin Journal of Chinese Medicine , 2017 , 37 ( 11 ): 1089 - 1091 .
陈钢 . 正邪关系补论 [J]. 成都中医药大学学报 , 2005 , 28 ( 1 ): 1 - 3 .
G Chen . Supplementary discussion on the relationship between vital qi and pathogenic qi [J]. Journal of Chengdu University of TCM , 2005 , 28 ( 1 ): 1 - 3 .
刘俊杰 , 肖长江 , 李姿蓉 , 等 . 运用辩证法解析争议中的“和法” [J]. 北京中医药大学学报 , 2016 , 39 ( 6 ): 449 - 451 .
JJ Liu , CJ Xiao , ZR Li , et al . Using dialectics to discuss the controversial “harmonizing therapy” [J]. Journal of Beijing University of Traditional Chinese Medicine , 2016 , 39 ( 6 ): 449 - 451 .
莫秀云 , 何旭敏 , 詹乐昌 . 浅谈“以毒攻毒”蕴含的中医邪正统一关系 [J]. 中医研究 , 2004 , 17 ( 2 ): 6 - 7 .
XY Mo , XM He , LC Zhan . Discussion on the unified relationship between vital qi and pathogenic qi of traditional Chinese medicine in “combatting poison with poison” [J]. Traditional Chinese Medicinal Research , 2004 , 17 ( 2 ): 6 - 7 .
李晨旭 , 孟丹华 , 陈玉龙 . 陈玉龙谈恶气与肿瘤 [J]. 中医药导报 , 2019 , 25 ( 20 ): 19 - 21,28 .
CX Li , DH Meng , YL Chen . CHEN Yu-long Talks about Un-Vital qi and tumor [J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy , 2019 , 25 ( 20 ): 19 - 21,28 .
陈玉龙 , 司富春 , 王庆其 . 恶气与肿瘤病机关系探讨 [J]. 河南中医学院学报 , 2004 , 19 ( 6 ): 9 - 11 .
YL Chen , FC Si , QQ Wang . Pathogenic factors and pathogenesis of tumor [J]. Journal of Henan University of Chinese Medicine , 2004 , 19 ( 6 ): 9 - 11 .
王书杰 , 张永琴 , 韦艾凌 . 浅论痰瘀在原发性肝癌发生、发展及转移中的作用 [J]. 中国中医基础医学杂志 , 2012 , 18 ( 9 ): 957 - 958,961 .
SJ Wang , YQ Zhang , AL Wei . Discussion on the role of phlegm and blood stasis in primary hepatocellular carcinoma occurrence, development and metastasis [J]. Journal of Basic Chinese Medicine , 2012 , 18 ( 9 ): 957 - 958,961 .
邹子骅 , 李峻岭 . 肿瘤微环境的理论及治疗进展 [J]. 癌症进展 , 2019 , 17 ( 23 ): 2737 - 2740,2780 .
ZH Zou , JL Li . Theories and treatment progress of tumor microenvironment [J]. Oncology Progress , 2019 , 17 ( 23 ): 2737 - 2740,2780 .
K Kim , YJ Sohn , R Lee , et al . Cancer-associated fibroblasts differentiated by exosomes isolated from cancer cells promote cancer cell invasion [J/OL]. Int J Mol Sci , 2020 ( 21 ): 8153 [ 2020-08-07 ]. https://doi.org/10.3390/ijms21218153 https://doi.org/10.3390/ijms21218153 .
张超 , 王晓林 , 李晨辉 , 等 . 肿瘤与免疫细胞通过外泌体相互作用的研究进展 [J]. 肿瘤学杂志 , 2020 , 26 ( 6 ): 469 - 474 .
C Zhang , XL Wang , CH Li , et al . Research progress on the interaction between tumor and immune cells through exosomes [J]. Journal of Chinese Oncology , 2020 , 26 ( 6 ): 469 - 474 .
顾军花 , 刘嘉湘 . 刘嘉湘教授“扶正治癌”理论核心及运用方法 [J]. 中国中西医结合杂志 , 2017 , 37 ( 4 ): 495 - 499 .
JH Gu , JX Liu . Core theory and application of Professor Liu Jiaxiang's theory on “strengthening vital qi to treat cancer” [J]. Chinese Journal of Integrated Traditional and Western Medicine , 2017 , 37 ( 4 ): 495 - 499 .
李黎 , 周雍明 , 朴炳奎 . 朴炳奎治疗恶性肿瘤“和其不和”学术思想探究 [J]. 中国中医药图书情报杂志 , 2018 , 42 ( 3 ): 67 - 69 .
L Li , YM Zhou , BK Piao . Research on Piao Bing-kui's academic thoughts of malignant tumor treatment by “regulating the imbalance of the body” [J]. Chinese Journal of Library and Information Science for Traditional Chinese Medicine , 2018 , 42 ( 3 ): 67 - 69 .
李惠惠 , 李全富 . 扶正解毒方对小鼠前胃癌诱导肿瘤相关巨噬细胞的影响 [J]. 吉林中医药 , 2016 , 36 ( 9 ): 922 - 925 .
HH Li , QF Li . Centralizer detoxification treatment of mice induced by gastric cancer before cancer research [J]. Jilin Journal of Chinese Medicine , 2016 , 36 ( 9 ): 922 - 925 .
黎金华 , 田菲 , 邱崇笙 , 等 . 扶正散结方调控Lewis肺癌小鼠TAMs免疫重塑作用的相关研究 [J]. 中国中药杂志 , 2015 , 40 ( 6 ): 1161 - 1165 .
JH Li , F Tian , CS Qiu , et al . Relevant studies on effect of Fuzheng Sanjie recipe in regulating immune microenvironment remodeling of TAMs in lewis lung cancer mice [J]. China Journal of Chinese Materia Medica , 2015 , 40 ( 6 ): 1161 - 1165 .
苏乐 . 健脾化瘀方通过miRNA-570调控B7-H1/PD-1通路防治肝癌术后复发的体内机制 [D]. 广州 : 广州中医药大学 , 2017 .
L Su . Preventive and therapeutic effect of Jianpi Huayu decoction on postoperative recurrence of hepatocellular carcinoma by regulating B7-H1/PD-1 pathway through miRNA-570 [D]. Guangzhou : Guangzhou University of Chinese Medicine , 2017 .
0
浏览量
20
下载量
6
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621