Objective

2

We aimed to explore the correlation between depression in patients with unstable angina pectoris after coronary revascularization and the levels of platelet (PLT)

total lymphocyte count (TLC)

platelet-lmphocyte ratio (PLR)

and total bilirubin (TBIL) and specific TCM syndromes.

Methods

2

Altogether 87 patients with unstable angina pectoris after coronary revascularization from November 2020 to July 2021 were selected. Laboratory examination was conducted after admission

including PLT

TLC

and TBIL values. The PLR was obtained by calculating the ratio of PLT and TLC. On the same day

the patient's Hamilton Depression Scale (HAMD) score was collected. Patients with a score between 8 and 24 were included in the depression group (42 cases); patients with a score below 8 were included in the control group (45 cases). Bivariate Spearman correlation analysis was conducted to investigate the relationship between each laboratory examination indices (PLT

TLC

TBIL

and PLR) and depression. Then

depression was taken as a dependent variable and each above laboratory examination index was taken as an independent variable to conduct binary Logistic regression analysis to determine the influencing factors. TCM syndromes (qi stagnation and blood stasis syndrome

qi stagnation and phlegm stagnation syndrome

and syndrome of qi depression transforming into fire) were classified by assigning values of 1 and 0

and Spearman correlation analysis was conducted. Then

the subjects were divided into compliance and non-compliance subgroups according to different TCM syndromes

and the independent sample t-test was conducted for laboratory examination indices with statistical significance in Spearman correlation analysis.

Results

2

PLT (

r

=0.312

P

=0.003) and PLR (

r

=0.486

P

<

0.001) were positively correlated with the occurrence of depression

while TLC (

r

=-0.296

P

=0.005) and TBIL (

r

=-0.424

P

<

0.001) were negatively correlated with the occurrence of depression. PLT was positively correlated with the occurrence of qi stagnation and blood stasis syndrome (

r

=0.354

P

=0.001)

and TLC (

r

=-0.229

P

=0.033) and PLR (

r

=0.293

P

= 0.006) were negatively or positively correlated with the occurrence of syndrome of qi depression transforming into fire

respectively.

Conclusion

2

PLR is an independent risk factor for depression in patients with unstable angina pectoris after coronary revascularization

and TBIL is a protective factor. High levels of PLT are closely related to the occurrence of qi stagnation and blood stasis syndrome

and high levels of TLC and PLR are related to the occurrence of syndrome of qi depression transforming into fire.