This article will explore the connotation of pivot from the perspective of ,Huangdi Neijing, and elaborate on the relationship between the Shaoyang pivot, the Shaoyin pivot, and depression. Based on the view that the pivots of Shaoyang and Shaoyin are unfavorable, qi is not disordered, and yang is not expressed, which are the key pathogenesis of depression, this article will elaborate on the clinical diagnosis and treatment principles of depression. In addition, it will introduce the main treatment principles of depression, including regulating the pivot to improve spirit, turning the pivot to inspire yang, and warming yang to resolve depression. Based on the clinical application of ,Shanghan Lun, appropriate prescriptions will be selected for modification. The main formula for regulating yang pivot is ,Chaihu Guizhi, Decoction, while the main formula for regulating yin pivot is ,Mahuang Fuzi Xixin, Decoction. At the same time, attention will be paid to indirectly regulating the pivot based on the development process of the disease, with flexible modification of medication. Finally, it will summarize the treatment ideas of depression, emphasizing on regulating pivot, aiming to alleviate or reduce the further development of the disease and explore new clinical treatment ideas for depression.