北京中医药大学中医学院 北京 100029
刘骐瑞,男,在读本科生
#鲁艺,女,博士,教授,副主任医师,硕士生导师,主要研究方向:中医药治疗精神神经系统疾病,E-mail:luyi@bucm.edu.cn
扫 描 看 全 文
刘骐瑞, 王禹童, 李永浩, 等. 基于气机升降理论探讨花、子、梗、藤药物在郁证治疗中的作用[J]. 北京中医药大学学报, 2023,46(12):1641-1647.
LIU Qirui, WANG Yutong, LI Yonghao, et al. Discussion on the application of special parts of plants " flowers, seeds, stems, and vine" in the treatment of depression based on theory the of qi movement[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(12):1641-1647.
刘骐瑞, 王禹童, 李永浩, 等. 基于气机升降理论探讨花、子、梗、藤药物在郁证治疗中的作用[J]. 北京中医药大学学报, 2023,46(12):1641-1647. DOI: 10.3969/j.issn.1006-2157.2023.12.003.
LIU Qirui, WANG Yutong, LI Yonghao, et al. Discussion on the application of special parts of plants " flowers, seeds, stems, and vine" in the treatment of depression based on theory the of qi movement[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(12):1641-1647. DOI: 10.3969/j.issn.1006-2157.2023.12.003.
气机的升降运动维持着人体正常生理功能,气机升降失常、郁滞不通则变生郁证,因此治疗郁证重在调畅气机、恢复气机正常升降运动。中医的“法象药理”理论将植物入药部位与药性升降相关联,在临床实践中多有证实。本文选取治疗郁证的常用药物中具有特殊性和代表性的植物花、子、梗、藤入药部位,借助气机升降理论,解析花类药、子类药、梗类药和藤类药在郁证治疗中,在调节气机升降运动和脏腑关系中发挥的重要作用。花类药轻清升散,具有调理气血、芳香怡神的作用;子类药沉实降敛,具有去除兼邪、润养安神的作用;梗、藤类药枢转通达,具有枢转斡旋、通达络脉的作用。花、子、梗、藤类药物能够调节气机的升降运动,在治疗郁证时配伍应用,能够充分发挥中医药治疗特色。通过总结特色用药规律,希望能够发挥中药药性理论优势,拓宽临床的选药范围,启发新的治疗思路。
The normal ascending and descending movements of qi maintain the physiological functions of the human body. If qi rises and falls abnormally or stagnates, this can result in depression. Therefore, the treatment of depression focuses on the regulation of qi movement and restoration of its ascending and descending circulation. Traditional Chinese medicine(TCM) has pharmacological theory based on the correspondence between nature, human, and herbs, which associates the medicinal parts of plants with the characteristics of ascending and descending of medicinal action. This theory has been widely confirmed in clinical practice. In this article, we discuss the special parts of plants, flowers, seeds, stems, and vine, used in the treatment of depression in the context of ascending and descending of qi movement. We analyze the important role of flower drugs, seed drugs, stem drugs, and vine drugs in regulating qi ascending and descending movement and the relationship between viscera in the treatment of depression. We believe that flower drugs are light and clear and have the role of "regulating qi and blood, fragrant and refreshing" ; seed drugs have the effect of "removing pathogenic factors, nourishing and calming the mind" ; and stem and vine drugs have the function of "pivoting to mediate and unblock collaterals." We hope to leverage the theoretical advantages of TCM, broaden the selection of clinical medicinals, and provide new treatment ideas.
气机升降郁证花类药子类药梗类药藤类药
the ascending and descending of qi movementdepressionflower drugseed drugstem drugvine drug
薛博瑜,吴伟. 中医内科学[M]. 3版. 北京:人民卫生出版社,2016: 284.
徐春甫. 古今医统大全(中)[M]. 项长生,点校. 合肥:安徽科学技术出版社,1995: 240.
张志聪. 张志聪医学全书[M]. 北京:中国中医药出版社,1999: 1074.
刘完素. 素问玄机原病式[M].宋乃光,点校.北京:中国中医药出版社,2007: 15.
朱震亨. 丹溪心法[M]. 彭建中,点校.沈阳:辽宁科学技术出版社,1997:64.
巢元方. 诸病源候论[M]. 黄作阵,点校.沈阳:辽宁科学技术出版社,1997: 70.
周学海.读医随笔[M].闫志安,周鸿艳,校注. 北京:中国中医药出版社,2007: 170.
张景岳. 类经[M]. 范志霞,校注.北京:中国医药科技出版社,2011: 455.
朱震亨. 格致余论[M]. 石学文,点校.沈阳:辽宁科学技术出版社,1997: 11.
朱震亨. 局方发挥[M]. 胡春雨,马湃,点校.天津:天津科学技术出版社,2011:26.
李时珍. 本草纲目:新校注本[M].刘衡如,刘山永,校注. 3版.北京:华夏出版社,2008.
高士栻. 医学真传[M]. 宋咏梅,李圣兰,点校.天津:天津科学技术出版社,2000: 45.
张伯龙,问.唐容川,答. 本草问答评注[M]. 黄杰熙,评注.太原:山西科学教育出版社,1991: 76.
张秉成. 本草便读[M]. 上海:上海卫生出版社,1957.
左瑶瑶,王丽婷,陈守强. 花类药在心血管疾病中的应用[J]. 中西医结合心脑血管病杂志,2016, 14(12): 1430-1431.
范乙林,何聪,王晓素. 基于“平正轻灵”浅析花类药调理脾胃枢机之妙用[J]. 环球中医药,2022, 15(10): 1869-1872.
王浩,赵明,杜冠潮,等. 基于“轻可去实”探讨花类药治疗慢性前列腺炎[J]. 江苏中医药,2022, 54(9): 13-16.
赵学敏. 本草纲目拾遗[M]. 闫冰,校注.北京:中国中医药出版社,1998: 245.
李志庸,主编.张景岳医学全书[M]. 北京:中国中医药出版社,1999: 1487.
佚名. 神农本草经[M]. 陈德兴,校注.福州:福建科学技术出版社,2012.
张山雷. 本草正义[M]. 程东旗,点校.福州:福建科学技术出版社,2006.
蔡群慧,徐斌. 徐斌运用花类药临证经验探析[J]. 中国民间疗法,2020, 28(11): 35-37.
胡慧娟. 马大正运用花类药物治疗妇科疾病的经验[J]. 江苏中医药,2015, 47(8): 25-27.
周胜利,蔡永亮. 蔡永亮教授运用花类药治疗抑郁性疾病的经验总结[J]. 中国中医药现代远程教育,2016, 14(22): 73-74.
UENO H, SHIMADA A, SUEMITSU S, et al. Anti-depressive-like effect of 2-phenylethanol inhalation in mice[J]. Biomed Pharmacother, 2019, 111: 1499-1506.
MATIAS NASCIMENTO MAIA W, DAS CHAGAS PEREIRA DE ANDRADE F, ALVES FILGUEIRAS L, et al. Antidepressant activity of rose oxide essential oil: possible involvement of serotonergic transmission[J/OL]. Heliyon, 2021, 7(4): e06620[2023-07-10].https://sciencedirect.com/science/article/pii/S2405844021007234?via%3Dihubhttps://sciencedirect.com/science/article/pii/S2405844021007234?via%3Dihub.
NA JR, OH DR, HAN SH, et al. Antistress effects of Rosa rugosa thunb. on total sleep deprivation-induced anxiety-like behavior and cognitive dysfunction in rat: possible mechanism of action of 5-HT6 receptor antagonist[J]. J Med Food, 2016, 19(9): 870-881.
刘倩佟,刘洁,郭建友,等. 合欢花总黄酮抗焦虑作用研究[J]. 现代中药研究与实践,2015, 29(2): 33-35.
XIONG WC, WU HZ, XIONG YY, et al. Network pharmacology-based research of active components of albiziae flos and mechanisms of its antidepressant effect[J]. Curr Med Sci, 2020(1): 123-129.
MA ZX, ZHANG RY, RUI WJ, et al. Quercetin alleviates chronic unpredictable mild stress-induced depressive-like behaviors by promoting adult hippocampal neurogenesis via FoxG1/CREB/BDNF signaling pathway[J/OL]. Behav Brain Res, 2021, 406: 113245[2023-07-10]. https://sciencedirect.com/science/article/pii/S0166432821001339?via%3Dihubhttps://sciencedirect.com/science/article/pii/S0166432821001339?via%3Dihub.
张彦,祝晨蔯. 金丝桃苷对慢性不可预知温和刺激大鼠抑郁行为的影响[J]. 中国新药与临床杂志,2017, 36(3): 150-156.
卢仁睿,张莉,徐瑞豪,等. 怀菊花提取物对皮质酮诱导的抑郁模型的保护作用及机制研究[J]. 中草药,2022, 53(18): 5750-5758.
卢弢,许隽,俞斐. 厚朴酚对抑郁模型大鼠海马神经可塑性的影响[J]. 中草药,2018, 49(20): 4844-4850.
刘辉,孙文平,杨光,等. 对种子类中药药性的初步分析[J]. 中国中药杂志,2004, 29(3): 283.
李用粹. 证治汇补[M]. 上海:上海卫生出版社,1958: 109.
吴仪洛. 本草从新[M]. 曲京峰,窦钦鸿,点校. 天津:天津科学技术出版社,2003: 40.
郭佩兰. 本草汇[M]. 郭君双,校注. 北京:中国中医药出版社,2015:464.
陈士铎. 石室秘录[M]. 北京:中国中医药出版社,2019: 4.
侯森泷,张福利. 《徐批叶天士晚年方案真本》虚劳病治法撷英[J]. 中华中医药杂志,2022, 37(4): 2348-2351.
汪昂. 本草备要[M]. 余力,陈赞育,校注.北京:中国中医药出版社,1998.
何钰珺,闫鹏轩,谢道俊. 谢道俊教授用“轻可去实、重可去怯”法治疗失眠伴焦虑抑郁状态经验[J]. 吉林中医药,2023, 43(6): 656-661.
田径,刘朴霖,刘建民,等. 张志远分型辨治郁证经验[J]. 中医杂志,2022, 63(19): 1820-1823.
叶娜妮,何若苹. 情志病治疗经验探析[J]. 中华中医药杂志,2021, 36(12): 7145-7147.
LEE JH, CHO YS. Assessment of phenolic profiles from various organs in different species of Perilla plant (Perilla frutescens (L.) Britt.) and their antioxidant and enzyme inhibitory potential[J/OL]. Ind Crops Prod, 2021, 171: 113914[2023-07-10]. https://sciencedirect.com/science/article/pii/S0926669021006786?via%3Dihubhttps://sciencedirect.com/science/article/pii/S0926669021006786?via%3Dihub.
杜艳,殷丽君,朱巧梅,等. 紫苏油的药理活性及其缓释技术研究进展[J]. 河南工业大学学报(自然科学版), 2016, 37(4): 114-117.
TERUSZKIN BALASSIANO I, ALVES DE PAULO S, HENRIQUES SILVA N, et al. Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model[J]. Int J Mol Med, 2002, 10(6): 785-788.
DAHCHOUR A. Anxiolytic and antidepressive potentials of rosmarinic acid: a review with a focus on antioxidant and anti-inflammatory effects[J]. Pharmacol Res, 2022, 184: 106421[2023-07-10]. https://www.sciencedirect.com/science/article/pii/S1043661822003668?via%3Dihubhttps://www.sciencedirect.com/science/article/pii/S1043661822003668?via%3Dihub.
LIU J, ZHAI WM, YANG YX, et al. GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice[J]. Pharmacol Biochem Behav, 2015, 128: 41-49.
LI HT, LI JN, ZHANG T, et al. Antidepressant effect of Jujuboside A on corticosterone-induced depression in mice[J]. Biochem Biophys Res Commun, 2022, 620: 56-62.
杨奕. 酸枣仁生物碱部位质量控制方法及其抗抑郁作用机制的研究[D]. 天津:天津医科大学,2013.
曲书阅,衡霞,戚懿予,等. 栀子总环烯醚萜对抑郁模型小鼠神经递质的影响[J]. 中成药,2021, 43(4): 1022-1027.
许彤辉,施玉樑,任小梅,等. 神经肌肉接头前阻断剂川楝素抑制大鼠大脑皮层突触体谷氨酸释放[J]. 中国药理学与毒理学杂志,2004, 18(5): 321-326.
徐大椿. 神农本草经百种录:附药性切用[M]. 伍悦,点校. 北京:学苑出版社,2011:300.
吴瑭.温病条辨[M].宋咏梅,臧守虎,张永臣,点校.北京:中国中医药出版社,2006: 252.
贾所学.药品化义[M]. 王小岗,郑玲,校注. 北京:中医古籍出版社,2012: 33.
王士雄. 随息居饮食谱[M]. 宋咏梅,张传友,点校.天津:天津科学技术出版社,2003: 58.
李小婷,徐菁,张静,等. 段行武运用藤类药“通络”治疗皮肤病经验[J]. 中医药导报,2022, 28(11): 125-128.
赵心华,王庆其,夏梦幻,等. 王庆其运用《内经》理论辨治郁证经验撷英[J]. 上海中医药杂志,2020, 54(4): 72-76.
罗明理,孙凤霞,李晓玲,等. 孙凤霞运用解郁合欢汤加减治疗慢性乙型病毒性肝炎合并郁证经验[J]. 中医药导报,2020, 26(8): 87-90.
易正珩,赖新生. 从“神-元气”论治郁证经验[J]. 中华中医药杂志,2022, 37(6): 3211-3215.
孙康. 马桂文教授治疗妇科郁证的用药规律及临床体会[J]. 陕西中医学院学报,2000, 23(5): 13-14.
戴家超,谢文强,何晓晖. 何晓晖应用越鞠丸治疗难治性疾病经验[J]. 中医药通报,2016, 15(1): 26-28.
WANG XF, HUANG YF, WANG L, et al. Photo-protective activity of pogostone against UV-induced skin premature aging in mice[J]. Exp Gerontol, 2016, 77: 76-86.
齐珊珊,胡丽萍,陈文娜,等. 广藿香叶挥发油对小鼠免疫调节作用的实验研究[J]. 中华中医药学刊,2009, 27(4): 774-776.
XU JJ, LI XQ, HU XM, et al. Pogostone attenuates traumatic brain injury-induced inflammatory response and neurological damage via regulating NF-kappa B and PPAR-gamma pathways[J]. J Biol Regul Homeost Agents, 2021, 35(4): 1245-1253.
程灿,潘超美,吴婕,等. 引种的印尼广藿香和肇庆广藿香不同部位挥发油气相色谱-质谱联用分析[J]. 中药新药与临床药理,2021, 32(4): 546-551.
曹亚飞,张延红,芦晔,等. 荷梗水提物对慢性应激所致抑郁小鼠学习记忆及蛋白激酶C表达的影响[J]. 中国新药杂志,2021, 30(7): 633-638.
张延红,曹亚飞,赵亚男,等. 荷梗对慢性应激小鼠的抗抑郁作用及其对TPH2和β CaMKII表达的影响[J]. 中成药,2020, 42(10): 2748-2751.
HE Y, ZENG SY, ZHOU SW, et al. Effects of rhynchophylline on GluN1 and GluN2B expressions in primary cultured hippocampal neurons[J]. Fitoterapia, 2014, 98: 166-173.
孙洲亮,文莉. 夜交藤不同提取物对抗焦虑作用的比较[J]. 中国医院药学杂志,2008, 28(2): 164-165.
吴达. 医学求是[M].王新华,点注. 南京:江苏科学技术出版社,1984: 13.
缪希雍.神农本草经疏[M].夏魁周,赵瑗,校注. 北京:中国中医药出版社,1997: 9.
0
浏览量
0
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构