基于病因学理论探讨肠道菌群失调之六淫属性

王俞铧; 梁笑妍; 陈昊昱; 任雪童; 杨天笑; 刘少伟; 王彦刚

doi:10.3969/j.issn.1006-2157.2023.12.006

您当前的位置：

首页 >

文章列表页 >

基于病因学理论探讨肠道菌群失调之六淫属性

理论研究 | 更新时间：2024-01-03

- 基于病因学理论探讨肠道菌群失调之六淫属性
- Exploring the characteristics of six climatic exopathogens causing intestinal flora dysregulation based on etiological theory
- 北京中医药大学学报 2023年46卷第12期页码：1658-1664
- 作者机构：
  
  1.河北中医药大学第一附属医院　石家庄　050091
  2.广州中医药大学第八临床医学院
  3.北京中医药大学第三附属医院
- 作者简介：
  
  王俞铧，女，在读博士生
  #王彦刚，男，博士，教授，主任医师，博士生导师，主要研究方向：中医药治疗脾胃疾病，E-mail: piwei001@163.com
- 基金信息：
  
  河北省自然科学基金资助项目(H2020423207);北京市自然科学基金资助项目(7232281);河北省中医药管理局科研计划项目(2024097;2024012)
- DOI：10.3969/j.issn.1006-2157.2023.12.006
  中图分类号：
扫描看全文
王俞铧, 梁笑妍, 陈昊昱, 等. 基于病因学理论探讨肠道菌群失调之六淫属性[J]. 北京中医药大学学报, 2023,46(12):1658-1664.

WANG Yuhua, LIANG Xiaoyan, CHEN Haoyu, et al. Exploring the characteristics of six climatic exopathogens causing intestinal flora dysregulation based on etiological theory[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(12):1658-1664.
王俞铧, 梁笑妍, 陈昊昱, 等. 基于病因学理论探讨肠道菌群失调之六淫属性[J]. 北京中医药大学学报, 2023,46(12):1658-1664. DOI： 10.3969/j.issn.1006-2157.2023.12.006.

WANG Yuhua, LIANG Xiaoyan, CHEN Haoyu, et al. Exploring the characteristics of six climatic exopathogens causing intestinal flora dysregulation based on etiological theory[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(12):1658-1664. DOI： 10.3969/j.issn.1006-2157.2023.12.006.

摘要

肠道菌群与疾病之间的关系是目前的研究热点，但多倾向于对其因果关系及发病机制的阐述，尚缺乏病因学视角下肠道微生态紊乱的中医特色探讨，混杂菌群的中医致病特点亟待进一步厘清。肠道菌群是机体内部与外界环境沟通的重要桥梁，在疾病的诊断、预后、治疗中扮演重要且复杂的角色。本文基于中医病因学理论，从肠道微生态紊乱的基本概念、形成原因、致病性质与特点等方面，结合神经系统、免疫系统、腺体分泌及营养代谢理论，以临床表现为依据，运用审症求因的方法，探讨肠道微生态紊乱导致风、火、燥、湿、寒变化的科学内涵。希望本文能为肠道菌群的中医学研究提供新的思路，补充、丰富病因学说内容，同时为肠道微生态紊乱可以促进各种复杂疾病的发生、发展的理解与研究提供新的理论依据。

Abstract

The relationship between intestinal flora and diseases is currently a hot topic of research, but most studies tend to explain causality and pathogenesis, and there is still a lack of studies of the traditional Chinese medicine (TCM) characteristics of intestinal microecological disorders from the perspective of etiology. The TCM pathogenic characteristics of hybrid flora need to be further clarified. The intestinal flora is an important bridge between the internal and the external environment of body, and plays an important and complex role in the diagnosis, prognosis, and treatment of diseases. Based on the etiology theory of TCM, this paper discusses the scientific connotation of changes of wind, fire, dryness, dampness, and cold caused by intestinal microecological disorder from the aspects of basic concepts, formation causes, and pathogenic nature and characteristics, combined with the nervous system, immune system, gland secretion, and nutritional metabolism, based on clinical manifestations, using the method of examining symptoms and seeking causes. This paper provides a new idea for the study of intestinal flora in TCM, and supplements and enriches the theory of etiology. At the same time, it provides an innovative theoretical basis for the understanding and research that intestinal microecological disorders can promote the occurrence and development of various complex diseases.

关键词

肠道菌群肠道微生态紊乱菌群失调病因学说

Keywords

intestinal floraintestinal microecological disordersdysbacteriosisetiological theory

references

TROPINI C, EARLE KA, HUANG KC, et al. The gut microbiome: connecting spatial organization to function [J]. Cell Host Microbe, 2017, 21(4): 433－442.

ASNICAR F, BERRY SE, VALDES AM, et al. Microbiome connections with host metabolism and habitual diet from 1，098 deeply phenotyped individuals [J]. Nat Med, 2021, 27(2): 321－332.

TANES C, BITTINGER K, GAO Y, et al. Role of dietary fiber in the recovery of the human gut microbiome and its metabolome [J]. Cell Host Microbe, 2021, 29(3): 394－407.

TARALLO S, FERRERO G, DE FILIPPIS F, et al. Stool microRNA profiles reflect different dietary and gut microbiome patterns in healthy individuals [J]. Gut, 2022, 71(7): 1302－1314.

NAMASIVAYAM S, MAIGA M, YUAN WX, et al. Longitudinal profiling reveals a persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy[J/OL]. Microbiome, 2017, 5(1): 71[2023－06－25].https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-017-0286-2https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-017-0286-2.

WEERSMA RK, ZHERNAKOVA A, FU JY. Interaction between drugs and the gut microbiome [J]. Gut, 2020, 69(8): 1510－1519.

赵佳，向雪松. 生命不同阶段肠道菌群变化及其影响因素 [J]. 卫生研究，2020, 49(1): 155－159.

QIN YW, HAVULINNA AS, LIU Y, et al. Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort [J]. Nat Genet, 2022, 54(2): 134－142.

COX TO, LUNDGREN P, NATH K, et al. Metabolic control by the microbiome[J]. Genome Med, 2022，14(1)：80[2023－06－25]. https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01092-0https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01092-0.

张锡纯. 医学衷中参西录[M].太原：山西科学技术出版社，2009：485.

金珏，陈晓. 《黄帝内经》“肝风病证”对混合性焦虑抑郁障碍辨治的启示 [J]. 北京中医药大学学报，46(8): 1111－1116.

WANG Q, LUO YQ, RAY CHAUDHURI K, et al. The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options [J]. Brain, 2021, 144(9): 2571－2593.

ZHENG SY, LI HX, XU RC, et al. Potential roles of gut microbiota and microbial metabolites in Parkinson's disease [J/OL]. Ageing Res Rev, 2021, 69: 101347[2023－06－25]. https://www.sciencedirect.com/science/article/abs/pii/S1568163721000945?via%3Dihubhttps://www.sciencedirect.com/science/article/abs/pii/S1568163721000945?via%3Dihub.

BI MX, FENG LJ, HE JH, et al. Emerging insights between gut microbiome dysbiosis and Parkinson's disease: Pathogenic and clinical relevance [J/OL]. Ageing Res Rev, 2022, 82: 101759[2023－06－25]. https://www.sciencedirect.com/science/article/pii/S156816372200201X?via%3Dihubhttps://www.sciencedirect.com/science/article/pii/S156816372200201X?via%3Dihub.

MATHESON JT, HOLSINGER RMD. The role of fecal microbiota transplantation in the treatment of neurodegenerative diseases: A review [J/OL]. Int J Mol Sci, 2023, 24(2)：1001[2023－06－25]. https://www.mdpi.com/1422-0067/24/2/1001https://www.mdpi.com/1422-0067/24/2/1001.

莫瀚钧，郎林，柳理娜，等. 抑郁、焦虑状态人群的肠道菌群构成 [J]. 中国临床医学，2021, 28(3): 433－443.

SOCAŁA K, DOBOSZEWSKA U, SZOPA A, et al. The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders [J/OL]. Pharmacol Res, 2021, 172：105840[2023－06－25]. https://www.sciencedirect.com/science/article/pii/S1043661821004242?via%3Dihubhttps://www.sciencedirect.com/science/article/pii/S1043661821004242?via%3Dihub.

POSTLER TS, GHOSH S. Understanding the holobiont: how microbial metabolites affect human health and shape the immune system [J]. Cell Metab, 2017, 26(1): 110－130.

费伯雄．医醇剩义[M].王鹏，王振国，整理. 北京：人民卫生出版社，2006：46.

LIU B, YE D, YANG H, et al. Two-sample mendelian randomization analysis investigates causal associations between gut microbial genera and inflammatory bowel disease, and specificity causal associations in Ulcerative Colitis or Crohn's Disease [J/OL]. Front Immunol, 2022, 13: 921546[2023－06－25]. https://www.frontiersin.org/articles/10.3389/fimmu.2022.921546/fullhttps://www.frontiersin.org/articles/10.3389/fimmu.2022.921546/full.

ZHANG YZ, XIA GZ, NIE XJ, et al. Differences in manifestations and gut microbiota composition between patients with different henoch-schonlein purpura phenotypes[J/OL]. Front Cell Infect Microbiol, 2021, 11: 641997[2023－06－25]. https://www.frontiersin.org/articles/10.3389/fcimb.2021.641997/fullhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.641997/full.

QU ZH, TIAN PJ, YANG B, et al. Fecal microbiota transplantation for diseases: Therapeutic potential, methodology, risk management in clinical practice [J/OL]. Life Sci, 2022, 304：120719[2023－06－25]. https://www.sciencedirect.com/science/article/pii/S0024320522004192?via%3Dihubhttps://www.sciencedirect.com/science/article/pii/S0024320522004192?via%3Dihub.

ZHENG ML, ZHOU WH, HUANG CC, et al. A single-cell map of peripheral alterations after FMT treatment in patients with systemic lupus erythematosus [J/OL]. J Autoimmun, 2023, 135：102989[2023－06－25]. https://www.sciencedirect.com/science/article/pii/S0896841122001974?via%3Dihubhttps://www.sciencedirect.com/science/article/pii/S0896841122001974?via%3Dihub.

NEUMAN H, DEBELIUS JW, KNIGHT R, et al. Microbial endocrinology: the interplay between the microbiota and the endocrine system [J]. FEMS Microbiol Rev, 2015, 39(4): 509－521.

喻嘉言．医门法律[M].北京：中国医药科技出版社，2011：139.

王肯堂. 证治准绳[M].北京：人民卫生出版社，2014：18.

QI XY, YUN CY, PANG YL, et al. The impact of the gut microbiota on the reproductive and metabolic endocrine system [J/OL]. Gut Microbes, 2021, 13(1): 1－21[2023－06－25].https://www.tandfonline.com/doi/full/10.1080/19490976.2021.1894070https://www.tandfonline.com/doi/full/10.1080/19490976.2021.1894070.

孙雯颖，于琦，王美玲，等. 原发性干燥综合征患者肠道菌群特征分析 [J]. 中国微生态学杂志，2022, 34(7): 798－802.

ZHANG XY, YANG HB, ZHENG JP, et al. Chitosan oligosaccharides attenuate loperamide-induced constipation through regulation of gut microbiota in mice [J/OL]. Carbohydr Polym, 2021, 253：117218[2023－06－25]. https://www.sciencedirect.com/science/article/pii/S0144861720313916?via%3Dihubhttps://www.sciencedirect.com/science/article/pii/S0144861720313916?via%3Dihub.

王俊杰，谈善军，吴国豪. 肠道菌群在癌性恶病质营养代谢及治疗中的作用 [J]. 肠外与肠内营养，2021, 28(1): 49－54.

BONGERS KS, CHANDERRAJ R, WOODS RJ, et al. The gut microbiome modulates body temperature both in sepsis and health [J]. Am J Respir Crit Care Med, 2023, 207(8): 1030－1041.

张昌云，景彩，肖宁，等. 16S rDNA基因测序分析阳虚质人群肠道菌群特征的研究 [J]. 山东中医杂志，2020, 39(7): 697－703.

COWARDIN CA, SYED S, IQBAL N, et al. Environmental enteric dysfunction: gut and microbiota adaptation in pregnancy and infancy [J]. Nat Rev Gastroenterol Hepatol, 2023, 20(4): 223－237.

BARRATT MJ, AHMED T, GORDON JI. Gut microbiome development and childhood undernutrition [J]. Cell Host Microbe, 2022, 30(5): 617－626.

FARINI A, TRIPODI L, VILLA C, et al. Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin-deficient mice [J/OL]. EMBO Mol Med, 2023, 15(3): e16244[2023－06－25]. https://www.embopress.org/doi/full/10.15252/emmm.202216244https://www.embopress.org/doi/full/10.15252/emmm.202216244.

周月，杜珊，陈斌. 肠道微生态失衡理论的研究现状 [J]. 中国病原生物学杂志，2019, 14(7): 867－870.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

人参皂苷Rb₁、小檗碱及其联合应用对肥胖小鼠肠道菌群的影响

基于“土克水”理论探讨肠道菌群与绝经后骨质疏松症的关系

从“瘀毒互结”探讨结直肠癌的病机特点和治疗

首乌丸调节肠道菌群延缓D－半乳糖模型大鼠脑衰老作用及机制研究

基于16S rRNA测序研究芍药甘草汤对支气管哮喘小鼠肠道菌群的影响