基于细胞外囊泡阐释中医学理论现代科学内涵和中药治疗机制
增强出版Exploration the modern scientific connotations of traditional Chinese medicine theory and therapeutic mechanism of Chinese materia medica based on extracellular vesicles
- 北京中医药大学学报 2024年47卷第10期 页码：1333-1342
- 作者机构：
1.北京中医药大学东直门医院中医内科学教育部重点实验室 北京 100700
2.北京中医药大学心血管病研究院
3.北京中医药大学东直门医院气血研究实验室
- 作者简介：
[ "专家简介：", "赵明镜，女，研究员，博士生导师，博士后合作导师。现任北京中医药大学心血管病研究院副院长，北京中医药大学东直门医院气血研究实验室主任。中西医结合学会实验医学专业委员会副主任委员，中国医师协会中西医结合学会基础与转化医学专业委员会副主任委员。长期从事中西医结合心脑血管疾病的应用基础研究，在中医药防治心力衰竭、心力衰竭后认知功能障碍、动脉粥样硬化性疾病及细胞外囊泡研究方面有丰富的研究积累。主持国家自然科学基金项目6项，北京市自然科学基金重点项目等省部级课题3项。作为主要成员获国家科技进步二等奖1项、教育部科技进步一等奖2项、中西医结合学会科技进步一等奖1项、中华中医药学会科技进步一等奖1项。发表论文160余篇，作为第一作者或通信作者发表SCI论文26篇。培养研究生及博士后30余人。" ]
- 基金信息：国家自然科学基金面上项目(81973787;82104653);北京中医药大学揭榜挂帅项目(90011431110008);北京市通州区科技创新人才项目(JCON2023020)
DOI：10.3969/j.issn.1006-2157.2024.10.001
中图分类号： R54纸质出版日期：2024-10-30，
网络出版日期：2024-10-08，
收稿日期：2024-06-17，
- 稿件说明：
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赵明镜. 基于细胞外囊泡阐释中医学理论现代科学内涵和中药治疗机制[J]. 北京中医药大学学报, 2024,47(10):1333-1342.
ZHAO Mingjing. Exploration the modern scientific connotations of traditional Chinese medicine theory and therapeutic mechanism of Chinese materia medica based on extracellular vesicles[J]. Journal of Beijing University of Traditional Chinese Medicine, 2024,47(10):1333-1342.
赵明镜. 基于细胞外囊泡阐释中医学理论现代科学内涵和中药治疗机制[J]. 北京中医药大学学报, 2024,47(10):1333-1342. DOI： 10.3969/j.issn.1006-2157.2024.10.001.
ZHAO Mingjing. Exploration the modern scientific connotations of traditional Chinese medicine theory and therapeutic mechanism of Chinese materia medica based on extracellular vesicles[J]. Journal of Beijing University of Traditional Chinese Medicine, 2024,47(10):1333-1342. DOI： 10.3969/j.issn.1006-2157.2024.10.001.
摘要
细胞外囊泡由各种细胞分泌，携带母细胞来源的RNA、DNA、蛋白质和脂质等信息，介导细胞－细胞间和器官－器官间的信息交流，在疾病发生发展、诊断、治疗及药物靶向递送等领域具有重要价值，同时，也与中医学理论和中药治疗密切相关。气血津液理论和藏象学说是中医学的基本理论，细胞外囊泡属于“津液”范畴，可经血脉到达其他脏腑，干扰脏腑之间的关系，甚至造成脏腑关系失衡，从而引起疾病。中药(包括中成药和中草药)可以调节机体内源性细胞外囊泡的数量及其内容物含量以改善机体的病理状态，同时，中草药来源细胞外囊泡样颗粒是中药治疗疾病的主要药效物质形式之一。此外，细胞外囊泡还可作为载体，递送药物参与精准靶向治疗。探讨中医药与细胞外囊泡的关系可阐明中医学理论的现代科学内涵，并揭示中药发挥治疗作用的机制，发展以中药为基础的工程化细胞外囊泡将为临床治疗提供更多新策略。
Abstract
Extracellular vesicles (EVs) are secreted by various cells and carry information such as parent cell-derived RNA
DNA
proteins
and lipids. They mediate information exchange between cells and organs
playing a crucial role in disease occurrence and development
diagnosis
treatment
and targeted drug delivery. EVs are also closely associated with traditional Chinese medicine theories and treatments. The qi-blood-fluid and visceral outward manifestation theories are the fundamental theories of traditional Chinese medicine. EVs belong to the fluid category and can reach other viscera through the blood vessels. They regulate the relationship between the viscera or cause imbalances between the viscera
resulting in disease. Chinese materia medica
which primarily includes traditional Chinese patent medicines and simple preparations
and Chinese herbal medicine
can help regulate the quantity and content of endogenous EVs in the body to improve pathological conditions. Additionally
EV-like particles derived from herbal medicines are a major form of pharmacologically active substances that contribute to the therapeutic effects of Chinese medicine in treating diseases. Furthermore
EVs can also be used as carriers to deliver drugs for targeted therapy. Therefore
exploring the relationship between traditional Chinese medicine and EVs will elucidate the modern scientific connotation of traditional Chinese medicine theories and reveal the mechanism of Chinese materia medica. The development of engineered EVs based on Chinese materia medica will provide novel strategies for clinical treatment.
关键词
细胞外囊泡中医学理论中药中草药来源细胞外囊泡样颗粒
Keywords
extracellular vesiclestraditional Chinese medicine theoriesChinese materia medicaChinese herbal medicine-derived EV-like particles
references
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