Objective To investigate the influences of kidney tonics on bone mineral density （BMD） and level of estrogen （E

2

） of osteogonarthritis combined with osteoporosis after menopause. Method The patients with osteogonarthritis combined with osteoporosis after menopause （n=50） were divided randomly into two groups and given respectively Bushenzhuanggu Granules and Celecoxib Capsules for 3 months. The symptom integral

BMD and level of E

2

were detected before and after the treatment. Result In the treatment group the symptom integral

JOA integral were obviously alleviated （P

<

0.01） and BMD and level of E

2

were increased （P

<

0.01） after the treatment then that before the treatment. In the control group JOA integral was obviously alleviated （P

<

0.01） but symptom integral

BMD and level of E

2

were not changed after the treatment compared with that before the treatment （P

>

0.05）. Conclusion Kidney tonics have a synthetic therapeutic effect on osteogonarthritis combined with osteoporosis after menopause.