四逆散有效部位对嗅球损毁大鼠探索行为及学习记忆功能的影响

畅洪昇; 孙建宁; 石任兵; 王庆国; 张硕峰; 姬曼

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四逆散有效部位对嗅球损毁大鼠探索行为及学习记忆功能的影响

更新时间：2021-08-03

- 四逆散有效部位对嗅球损毁大鼠探索行为及学习记忆功能的影响
- Influences of effective fractions of Sini Powder on exploratory behavior, andabilities of learning and memory in rats with olfactory bulb lesion
- 北京中医药大学学报 2005年第4期页码：39-41
- 作者机构：
  
  1. 北京中医药大学
  2. 首都医科大学神科所,北京,100029
  3. ,北京,100054
- 作者简介：
- 基金信息：
  
  国家中医药管理局中医药科学技术研究专项（No.02-03ZP04）()
- DOI：
  中图分类号： R285.5
- 纸质出版日期：2005，
- 稿件说明：
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畅洪昇, 孙建宁, 石任兵, 等. 四逆散有效部位对嗅球损毁大鼠探索行为及学习记忆功能的影响[J]. 北京中医药大学学报, 2005,(4):39-41.

Chang Hongsheng, Sun Jianning, Shi Renbing, et al. Influences of effective fractions of Sini Powder on exploratory behavior, andabilities of learning and memory in rats with olfactory bulb lesion[J]. Journal of Beijing University of traditional Chinese Medicine, 2005,(4):39-41.
畅洪昇, 孙建宁, 石任兵, 等. 四逆散有效部位对嗅球损毁大鼠探索行为及学习记忆功能的影响[J]. 北京中医药大学学报, 2005,(4):39-41. DOI：

Chang Hongsheng, Sun Jianning, Shi Renbing, et al. Influences of effective fractions of Sini Powder on exploratory behavior, andabilities of learning and memory in rats with olfactory bulb lesion[J]. Journal of Beijing University of traditional Chinese Medicine, 2005,(4):39-41. DOI：

摘要

目的评价四逆散有效部位对嗅球损毁大鼠探索行为、学习记忆功能的影响。方法用敞箱和Morris水迷宫研究四逆散有效部位对嗅球损毁大鼠水平、垂直运动和学习记忆等行为学变化的影响。结果与模型组比较

四逆散有效部位大剂量、中剂量明显增加了嗅球损毁大鼠的垂直运动。学习记忆方面

四逆散有效部位治疗组潜伏期显著缩短

中小剂量组20%边缘区域运动明显缩短

80%中心区域运动增加。结论四逆散有效部位能改善大鼠嗅球损毁4周后出现的探索行为减少、学习记忆障碍。学习记忆的增强可能与四逆散有效部位发挥抗抑郁药样作用相关。

Abstract

objective To evaluate the influences of effective fractions of Sini Powder （EFSP） on the exploratory behavior

and abilities of learning and memory in rats with olfactory bulb lesion.Methods Open-field and Morris water maze were used to investigate the effects of EFSP on rat behavioural changes

such as horizontal and vertical movements

learning and memory abilities. Results Compared with the model group

high-and mid-dose of EFSP obviously improved the vertical movements in rats with olfactory bulb lesion. Of the learning and memory abilities

the latency period was obviously shortened in the treatment group. With mid-and low-dose of EFSP the movements in 20% of marginal zone were decreased and the movements in 80% of center zone were increased.Conclusion EFSP can relieve the decrease of exploratory behavior

and the disorder of memory and learning abilities in rats with olfactory bulb lesion. The improvement of memory and learning abilities may be related to the anti-depression effect of EFSP.

关键词

四逆散有效部位嗅球损毁模型行为学抗抑郁

Keywords

Sini Powdereffective fractionsrat model of olfactory bulb lesionbehavioural scienceanti-depression

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