Rheumatic immune diseases in children are difficult to treat

frequently recur

and can seriously affect children’s physical and mental health. At present

treatment of rheumatic immune diseases mainly depends on hormones

biologicals and immunosuppressants. However

these drugs have nonnegligible side effects. Traditional Chinese medicine deems that the side effects of drugs belong to the category of drug "toxicity". Drugs that are toxic are called "toxicity" drugs

with regard to "toxicity" drugs

the theory of "You Gu Wu Yun" in Inner canon of Huangdi considers that although drugs are "toxic

" drugs are used for an explicit "reason

" so the disease itself receives the drug first

which are not harmful to the human body. Based on this theory

we propose "toxicity" drugs’ use principles that "toxicity" drugs are severe; therefore

drugs should not be used until the plight is urgent. "Toxicity" drugs should be stopped when the disease is mostly cured. The "effectiveness" and "toxicity" must be weighed to find a balance between the body and the drugs. Treatment ought to be adapted according to personal condition

because tolerance to "toxicity" drugs varies. Drugs must be used based on disease differentiation and syndrome differentiation

and toxicity must be reduced by compatibility. We also put forward the "toxicity" drugs’ use strategies of precising drugs’ use

taking measures to attenuate toxicity

improving the benefit/risk ratio

which are of great guiding significance to the safe use of drug in pediatric clinics.