1.中国中医科学院广安门医院 北京 100053
2.中国中医科学院眼科医院
张富渊,男,在读博士生
# 姜泉,女,博士,主任医师,博士生导师,主要研究方向:中医药防治风湿免疫病,E-mail: doctorjq@126.com
纸质出版日期:2023-06-30,
网络出版日期:2023-04-26,
收稿日期:2022-12-13,
移动端阅览
张富渊, 姜泉, 王瑶, 等. 类风湿关节炎患者功能状态与湿热痹阻证候的相关性研究[J]. 北京中医药大学学报, 2023,46(6):820-825.
ZHANG Fuyuan, JIANG Quan, WANG Yao, et al. Correlation between functional status and damp-heat obstruction syndrome in patients with rheumatoid arthritis[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(6):820-825.
张富渊, 姜泉, 王瑶, 等. 类风湿关节炎患者功能状态与湿热痹阻证候的相关性研究[J]. 北京中医药大学学报, 2023,46(6):820-825. DOI: 10.3969/j.issn.1006-2157.2023.06.012.
ZHANG Fuyuan, JIANG Quan, WANG Yao, et al. Correlation between functional status and damp-heat obstruction syndrome in patients with rheumatoid arthritis[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(6):820-825. DOI: 10.3969/j.issn.1006-2157.2023.06.012.
目的
2
探讨类风湿关节炎患者功能状态与湿热痹阻证候的相关性。
方法
2
回顾性分析来自全国18家研究中心1 008例类风湿关节炎患者的病例资料,将患者分为湿热组和非湿热组,比较两组患者的X线分级、健康评估问卷(HAQ)残疾指数、28处关节疾病活动度评分(DAS28)、疼痛视觉模拟量表(VAS)评分、关节压痛数、关节肿胀数、部分实验室指标及一般资料。
结果
2
湿热组患者的X线等级、HAQ残疾指数、VAS评分、DAS28-红细胞沉降率(ESR)、关节压痛数、关节肿胀数均高于非湿热组(
P
<
0.05)。湿热组患者的血红蛋白、血小板、红细胞沉降率、抗环瓜氨酸肽抗体均高于非湿热组(
P
<
0.05)。2组患者的白细胞、类风湿因子、家族史、劳累史、情绪激动史、吸烟史、饮酒史等因素差异无统计学意义(
P
>
0.05)。
结论
2
类风湿关节炎患者功能状态与湿热痹阻证候密切相关,类风湿关节炎湿热痹阻证患者疾病活动度更高,致残程度更重。
Objective
2
We aimed to explore the correlation between the functional status of rheumatoid arthritis (RA) patients and damp-heat obstruction syndrome.
Methods
2
The case data of 1
008 patients with RA from 18 research centers of China were retrospectively analyzed
and the patients were divided into a damp-heat group and a non-damp-heat group. X-ray grades
a health assessment questionnaire (HAQ) disability index
disease activity score (DAS28)
visual analogue pain scales(VAS) score
joint tenderness number
joint swelling number
laboratory indexes
and general data of the two groups were compared.
Results
2
The X-ray grade
HAQ
VAS score
DAS28-ESR
joint tenderness number
and joint swelling number of the patients in the damp-heat group were higher than those of the patients in the non-damp-heat group (
P
<
0.05). The hemoglobin
platelet
erythrocyte sedimentation
and anti-cyclic citrullinated peptide antibody of patients in the damp-heat group were higher than those of the patients in the non-damp-heat group (
P
<
0.05). There were no differences in leukocytes
rheumatoid factor
family history
fatigue history
emotional history
smoking history
drinking history
or other factors between the two groups (
P
>
0.05).
Conclusion
2
The functional status of RA patients was closely related to the syndrome of damp-heat obstruction. The disease activity of RA patients with damp-heat obstruction syndrome was higher and the degree of disability was more severe.
湿热痹阻类风湿关节炎X线骨破坏
damp-heat obstruction syndromerheumatoid arthritisX-raybone destruction
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