基于“二阳之病发心脾”探讨肠道微生物群与不孕症的关系

郭佳易; 贺丰杰; 李楠

doi:10.3969/j.issn.1006-2157.2023.06.014

您当前的位置：

首页 >

文章列表页 >

基于“二阳之病发心脾”探讨肠道微生物群与不孕症的关系

临床研究 | 更新时间：2023-07-05

- 基于“二阳之病发心脾”探讨肠道微生物群与不孕症的关系
- The relationship between intestinal microbiota and infertility based on the theory of "the disease of double yang involve the heart and the spleen"
- 北京中医药大学学报 2023年46卷第6期页码：836-841
- 作者机构：
  
  1.陕西中医药大学　咸阳　712046
  2.陕西中医药大学附属医院
- 作者简介：
  
  郭佳易，女，在读硕士生
  # 李楠，女，博士，主任医师，硕士生导师，主要研究方向：中医药调节女性生殖内分泌，E-mail：linan_80_311@163.com
- 基金信息：
  
  国家自然科学基金项目(81603656);国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函〔2022〕75号);重大疑难疾病（不孕不育）中西医临床协作试点项目
- DOI：10.3969/j.issn.1006-2157.2023.06.014
  中图分类号： R271.14
- 纸质出版日期：2023-06-30，
  
  网络出版日期：2023-04-12，
  
  收稿日期：2022-08-28，
- 稿件说明：
移动端阅览
郭佳易, 贺丰杰, 李楠. 基于“二阳之病发心脾”探讨肠道微生物群与不孕症的关系[J]. 北京中医药大学学报, 2023,46(6):836-841.

GUO Jiayi, HE Fengjie, LI Nan. The relationship between intestinal microbiota and infertility based on the theory of "the disease of double yang involve the heart and the spleen"[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(6):836-841.
郭佳易, 贺丰杰, 李楠. 基于“二阳之病发心脾”探讨肠道微生物群与不孕症的关系[J]. 北京中医药大学学报, 2023,46(6):836-841. DOI： 10.3969/j.issn.1006-2157.2023.06.014.

GUO Jiayi, HE Fengjie, LI Nan. The relationship between intestinal microbiota and infertility based on the theory of "the disease of double yang involve the heart and the spleen"[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(6):836-841. DOI： 10.3969/j.issn.1006-2157.2023.06.014.

摘要

近年来，不孕症的发病率持续上升，且发病人群呈年轻化趋势，如何有效地防治该疾病亦成为临床面临的难题。肠道微生物群已被证实是人体内最大的内分泌器官，其通过多种途径调控宿主的代谢，与女性的生殖内分泌密切相关。“二阳之病发心脾”理论可从中医学角度为阐述肠道微生物群与不孕症的关系提供新思路，二阳即胃肠，作为人体与外界联系的通道最易感邪致病延及心脾，二阳为腑，传化物而不藏，为心脾提供物质基础，心脾又对二阳起调控作用。因此，在心脾主导下，二阳功能协调，精血合凝，则易成胎孕。基于“二阳之病发心脾”理论阐述其与肠道微生物群、不孕症相关性的基础上，进一步阐明运用“二阳之病发心脾”理论调节机体内稳态和防治不孕症的思路，以期为不孕症的治疗提供新的理论依据和临床指导。

Abstract

In recent years

the prevalence of infertility has continued to rise

and the incidence in the population has shown a trend toward younger individuals

how to prevent and treat the disease more effectively has become a difficult problem. The intestinal microbiota has been shown to be the largest endocrine organ of the human. It regulates the metabolism of the host through a variety of mechanisms and is closely related to women’s reproductive endocrine functions. The theory of "the disease of double yang involve the heart and the spleen" can provide a new idea for explaining the relationship between the intestinal microbiota and infertility from the perspective of traditional Chinese medicine. The two-yang are the stomach and intestines

and as the pathway between the human body and outside world

they are susceptible to disease

including those of the heart and spleen. The stomach and intestines belong to the six fu-organs

which transport and transform water and food without storage

providing a material basis for the heart and spleen

and in turn the heart and spleen play a regulatory role in the double yang. Therefore

under the guidance of the heart and spleen

the function of double yang is coordinated

the essence and blood are combined and condensed

and pregnancy will more likely result. Based on the theory of "the disease of double yang involve the heart and the spleen"

we elaborate the correlation between the theory and intestinal microbiota and infertility

and we further elucidate the use of this theory to regulate the body's homeostasis to prevent or treat infertility

in order to provide a new theoretical basis and clinical guidance for the treatment of infertility.

关键词

二阳之病发心脾肠道微生物群不孕症心脾

Keywords

the disease of the double yang involve the heart and the spleenintestinal microbiotainfertilityheartspleen

references

FU B, QIN N, CHENG L, et al. Development and validation of an Infertility Stigma Scale for Chinese women[J]. J Psychosom Res, 2015，79(1): 69－75.

CLEMENTE JC, URSELL LK, PARFREY LW, et al. The impact of the gut microbiota on human health: an integrative view[J]. Cell, 2012，148(6): 1258－1270.

TAMMA PD, MILLER MA, COSGROVE SE. Rethinking How Antibiotics Are Prescribed: Incorporating the 4 Moments of Antibiotic Decision Making Into Clinical Practice[J]. JAMA, 2019，321(2): 139－140.

张超，加秀凤，黄万凌，等. 首乌丸调节肠道菌群延缓D－半乳糖模型大鼠脑衰老作用及机制研究[J]. 北京中医药大学学报，2023，46(1)：65－76.

EDWARDS DP. Regulation of signal transduction pathways by estrogen and progesterone[J]. Annu Rev Physiol, 2005，67: 335－376.

FRANASIAK JM, SCOTT RJ. Introduction: Microbiome in human reproduction[J]. Fertil Steril, 2015，104(6): 1341－1343.

ROGERS GB, KEATING DJ, YOUNG RL, et al. From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways[J]. Mol Psychiatry, 2016，21(6): 738－748.

SCHMIDT T, RAES J, BORK P. The Human Gut Microbiome: From Association to Modulation[J]. Cell, 2018，172(6): 1198－1215.

RIDLON JM, IKEGAWA S, ALVES JM, et al. Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens[J]. J Lipid Res, 2013，54(9): 2437－2449.

COLLDEN H, LANDIN A, WALLENIUS V, et al. The gut microbiota is a major regulator of androgen metabolism in intestinal contents[J]. Am J Physiol Endocrinol Metab, 2019，317(6): 1182－1192.

GAJER P, BROTMAN RM, BAI G, et al. Temporal dynamics of the human vaginal microbiota[J]. Sci Transl Med, 2012，4(132): 132－152.

MORENO I, CODOÑER FM, VILELLA F, et al. Evidence that the endometrial microbiota has an effect on implantation success or failure[J]. Am J Obstet Gynecol, 2016，215(6): 684－703.

OMENETTI S, PIZARRO TT. The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome[J/OL]. Front Immunol，2015，6：639[2022－08－29].https：//www.frontiersin.org/articles/10.3389/fimmu.2015.00639/fullhttps：//www.frontiersin.org/articles/10.3389/fimmu.2015.00639/full.

GNAINSKY Y, ZFANYA N, ELGART M, et al. Systemic Regulation of Host Energy and Oogenesis by Microbiome-Derived Mitochondrial Coenzymes[J/OL]. Cell Rep, 2021，34(1): 108583 [2022－08－29]. https：//www.sciencedirect.com/science/article/pii/S2211124720315722？via%3Dihubhttps：//www.sciencedirect.com/science/article/pii/S2211124720315722？via%3Dihub.

SASAKI H, KAWAMURA K, KAWAMURA T, et al. Distinctive subpopulations of the intestinal microbiota are present in women with unexplained chronic anovulation[J]. Reprod Biomed Online, 2019，38(4): 570－578.

张介宾. 类经[M].郭洪耀，吴少祯，校注．北京：中国中医药出版社，1997.

周易[M].郭彧，校注. 北京：中华书局，2006：406－408.

卢林，杨景云，李丹红. 健脾渗湿汤对脾虚湿盛泄泻患者肠道微生态及舌部菌群影响的研究[J]. 中国微生态学杂志，2007，19(5): 439－441.

LIN Z, YE W, ZU XP, et al. Integrative metabolic and microbial profiling on patients with Spleen-yang-deficiency syndrome[J/OL]. Sci Rep, 2018，8(1): 6619[2022－08－29]. https：//www.ncbi.nlm.nih.gov/pmc/articles/PMC5920061/https：//www.ncbi.nlm.nih.gov/pmc/articles/PMC5920061/.

王海瑜，钱唐亮，康天伦，等. 肠道菌群与类风湿关节炎寒热证型相关性研究[J]. 中国中医药信息杂志，2020，27(6): 44－49.

封慧，朱欣轶，王长松. 健脾中药对肠道微生态作用机制研究进展[J]. 中国中医药信息杂志，2018，25(10): 137－140.

吴佳佳，李晓娟，陈家旭. 肠道微生态与中医证候的相关性研究概况[J]. 中医杂志，2018，59(14): 1247－1251.

郭宗耀，刘芸，高玉萍，等. “心与小肠相表里”理论的源流与发展[J]. 中医杂志，2017，58(2): 96－99.

李波，侍荣华，李宗杰. 肠道菌群－肠－脑轴与心身疾病的相互关系[J]. 生理科学进展，2018，49(3): 221－226.

傅山. 傅青主女科[M]. 申玮红，校注．北京：中国医药科技出版社，2011：26.

张景岳. 妇人规[M]. 北京：中国医药科技出版社，2017：85.

蓝裕君，谢波. 补肾健脾法治疗卵泡发育不良不孕症的疗效观察[J]. 广西医学，2020，42(4): 410－413.

缪希雍. 神农本草经疏[M]. 北京：中医古籍出版社，2017：149.

张璐. 本经逢原[M].赵小青，校注. 北京：中国中医药出版社，1996：64.

陈士铎. 本草新编[M].柳长华，校注. 北京：中国中医药出版社，1996：69.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

何氏养巢颗粒联合针灸治疗卵巢储备功能减退伴不孕症肾虚证患者的随机双盲对照研究

海派蔡氏妇科育肾周期疗法治疗不孕症的理论与实践

基于“上焦得通，津液得下，胃气因和”探讨胃食管反流病机制

“香入脾”理论发微

“脾为谏议之官”浅析