基于“燥热怫郁”理论探讨2型糖尿病肠黏膜屏障损伤

李嘉鑫; 王庆峰; 安继仁; 杨宇峰; 石岩

doi:10.3969/j.issn.1006-2157.2023.07.017

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基于“燥热怫郁”理论探讨2型糖尿病肠黏膜屏障损伤

理论研究 | 更新时间：2023-08-07

- 基于“燥热怫郁”理论探讨2型糖尿病肠黏膜屏障损伤
- Exploration of intestinal mucosal barrier injury in diabetes mellitus type 2 based on "dryness-heat and stagnation" theory
- 北京中医药大学学报 2023年46卷第7期页码：992-998
- 作者机构：
  
  辽宁中医药大学　沈阳　110847
- 作者简介：
  
  李嘉鑫，女，在读博士生
  # 杨宇峰，男，博士，教授，硕士生导师，主要研究方向：中西医结合防治糖尿病及代谢综合征，E-mail：yyf701@163.com
- 基金信息：
  
  国家重点基础研究发展计划项目(2013CB532004);辽宁省自然科学基金重点项目(20170540598);辽宁省“百千万人才工程”资助项目(2020921039);辽宁省“兴辽英才计划”青年拔尖人才资助项目(XLYC1807145)
- DOI：10.3969/j.issn.1006-2157.2023.07.017
  中图分类号： R259
- 纸质出版日期：2023-07-30，
  
  收稿日期：2022-12-13，
- 稿件说明：
移动端阅览
李嘉鑫, 王庆峰, 安继仁, 等. 基于“燥热怫郁”理论探讨2型糖尿病肠黏膜屏障损伤[J]. 北京中医药大学学报, 2023,46(7):992-998.

LI Jiaxin, WANG Qingfeng, AN Jiren, et al. Exploration of intestinal mucosal barrier injury in diabetes mellitus type 2 based on "dryness-heat and stagnation" theory[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(7):992-998.
李嘉鑫, 王庆峰, 安继仁, 等. 基于“燥热怫郁”理论探讨2型糖尿病肠黏膜屏障损伤[J]. 北京中医药大学学报, 2023,46(7):992-998. DOI： 10.3969/j.issn.1006-2157.2023.07.017.

LI Jiaxin, WANG Qingfeng, AN Jiren, et al. Exploration of intestinal mucosal barrier injury in diabetes mellitus type 2 based on "dryness-heat and stagnation" theory[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(7):992-998. DOI： 10.3969/j.issn.1006-2157.2023.07.017.

摘要

近年来，2型糖尿病(T2DM)的发病率逐渐增高。研究表明，肠黏膜屏障损伤与T2DM的发生发展关系密切，肠黏膜屏障是肠道内容物与机体血液循环之间的重要屏障，包括免疫屏障、机械屏障、化学屏障和生物屏障，各种肠黏膜屏障损伤过程中均存在肠道炎症反应，肠道炎症反应也是肠黏膜屏障损伤导致T2DM的关键因素。“燥热怫郁”理论是中医消渴病诊疗理论的重要组成部分，由刘完素在《三消论》中首先提出，并应用于临床实践。饮食不节、脾胃亏虚为致病之本，而脾胃虚弱与肠道消化吸收及黏膜屏障功能损伤密切相关。燥热内生、腠理怫郁是消渴病的关键病机，中医学燥热内生的病机演变颇切合西医学慢性炎症反应的病理特点，肠道腠理的作用与西医学肠黏膜屏障功能相吻合。因此，基于“燥热怫郁”理论探讨肠黏膜屏障损伤与T2DM的关系，可为中医学论治T2DM提供理论依据。

Abstract

In recent years

the incidence of diabetes mellitus type 2 (T2DM) has gradually increased. Studies have shown that intestinal mucosal barrier injury is closely related to the occurrence and development of T2DM. The intestinal mucosal barrier is an important barrier between intestinal contents and the body's blood circulation

including the immune barrier

the mechanical barrier

the chemical barrier

and the biological barrier. Intestinal inflammatory reactions take place in various processes of intestinal mucosal barrier injury

which is also a key factor in T2DM-induced intestinal mucosal barrier injury. As an important part of the traditional Chinese medicine diagnosis and treatment theory of emaciation-thirst disease

"dryness-heat and stagnation" was first proposed and applied in clinical practice in Liu Wansu’s

San Xiao Lun

. Improper diet and deficiency of the spleen and stomach are the root causes of the disease

and the weakness of the spleen and stomach is closely related to intestinal digestion and absorption and reduced mucosal barrier function. The endogenous dryness-heat and stagnation of striae and interstices is the key pathogenesis of emaciation-thirst. The evolution of pathogenesis of endogenous dryness-heat in traditional Chinese medicine is quite consistent with the pathological characteristics of a chronic inflammatory response in western medicine. The action of striae and interstices of the intestine is consistent with the function of the intestinal mucosal barrier in western medicine. Therefore

the relationship between intestinal mucosal barrier injury and T2DM is discussed based on "dryness-heat and stagnation" theory

which will provide a theoretical basis for the treatment of T2DM.

关键词

燥热怫郁肠黏膜屏障损伤2型糖尿病炎症反应

Keywords

dryness-heat and stagnationintestinal mucosal barrier injurydiabetes mellitus type 2inflammatory response

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