1.广西中医药大学针灸推拿学院 南宁 530001
2.湖南中医药大学针灸推拿与康复学院
蒋全睿,男,博士
# 李武,男,博士,副教授,硕士生导师,主要研究方向:推拿手法治病机制研究,E-mail: 272434694@qq.com
纸质出版日期:2023-07-30,
网络出版日期:2023-05-26,
收稿日期:2023-02-02,
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蒋全睿, 刘丹, 潘杰灵, 等. 不同部位按法对慢性疼痛激痛点大鼠模型的影响[J]. 北京中医药大学学报, 2023,46(7):1008-1019.
JIANG Quanrui, LIU Dan, PAN Jieling, et al. Effects of different site pressing on local myofascial trigger points in chronic pain model rats[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(7):1008-1019.
蒋全睿, 刘丹, 潘杰灵, 等. 不同部位按法对慢性疼痛激痛点大鼠模型的影响[J]. 北京中医药大学学报, 2023,46(7):1008-1019. DOI: 10.3969/j.issn.1006-2157.2023.07.020.
JIANG Quanrui, LIU Dan, PAN Jieling, et al. Effects of different site pressing on local myofascial trigger points in chronic pain model rats[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(7):1008-1019. DOI: 10.3969/j.issn.1006-2157.2023.07.020.
目的
2
观察局部按法、对侧按法和远端按法刺激对慢性疼痛激痛点大鼠模型局部的影响。
方法
2
将SPF级雄性SD大鼠随意分为空白组10只和造模组50只,以钝性击打结合离心运动法在大鼠左侧大腿内侧肌建立激痛点模型,造模成功后,符合评价标准大鼠随机数字表法分为模型组、局部按法组、对侧按法组和远端按法组,每组10只。空白组、模型组不予干预,其余各组分别以自制按法刺激器干预14 d,局部按法组以按法刺激激痛点局部,对侧按法组以按法刺激激痛点对侧肢体,远端按法组以按法刺激激痛点同侧“太溪”区域。以电生理仪器记录激痛点局部肌电图,以软组织张力测定器检测激痛点软组织张力,以压痛测试仪检测激痛点机械痛阈值。干预结束后取左侧大腿内侧肌或激痛点组织,HE染色观察病理形态,免疫组化和酶联免疫吸附测定检测P物质和降钙素基因相关肽(CGRP)含量。
结果
2
与空白组相比较,模型组机械痛阈值降低,软组织张力升高,自发电活动明显,形态学有明显改变,P物质和CGRP含量增加(
P
<
0.05);与模型组相比较,局部按法组、对侧按法组和远端按法组机械痛阈值提高,软组织张力、自发电位频率和振幅、P物质和CGRP含量降低(
P
<
0.05),其中,局部按法组变化幅度最大(
P
<
0.05)且对形态学改善作用明显,对侧按法组对肌电图、CGRP和P物质的改善作用优于远端按法组(
P
<
0.05)。
结论
2
局部按法、对侧肢体按法和远端“太溪”按法刺激均可以缓解激痛点疼痛,降低软组织张力和自发电活动,可能与抑制P物质和CGRP的高表达有关;激痛点局部按法的作用最佳,对侧按法次之,最后是远端“太溪”区域按法。
Objective
2
We aimed to investigate the differences in the effects of local pressing
contralateral pressing
and distal pressing stimulation on the local myofascial trigger points (MTrPs) in chronic pain model rats.
Methods
2
SPF-grade male Sprague-Dawley rats were randomly divided into the blank group (
n
=10) and the MTrPs group(
n
=50) in which the MTrPs model was established. The MTrPs model was established in the left medial thigh muscle of rats by blunt strikes combined with centrifugal exercise. Rats that met the evaluation criteria after modeling were randomly divided into the model group
the local pressing group
the contralateral pressing group
and the distal pressing group(
n
=10). Rats in the blank group and the model group did not undergo intervention
and the remaining groups were treated with homemade pressing stimulators for 14 days. The rats in the local pressing group
the contralateral pressing group
and the distal pressing group were subjected to pressing stimulation at their respective sites. Specifically
they received pressing stimulation locally on the MTrPs
on the contralateral limb of the MTrPs site
and at the ipsilateral KI3 area of the MTrPs
respectively. The electromyogram (EMG) was recorded and soft tissue tension and the mechanical pain threshold were detected by electrophysiological instruments
a soft tissue tension tester
and a pressure painmeter
respectively. At the end of the intervention
tissues from the left medial thigh muscle or MTrPs were taken to observe the pathological morphology using HE staining. In addition
SP and CGRP contents were measured using immunohistochemistry and ELISA.
Results
2
Compared with the blank group
the model group had a lower mechanical pain threshold
higher soft tissue tension
obvious spontaneous electrical activity
significant pathological changes
and increased SP and CGRP levels (
P
<
0.05). Compared with the model group
the local pressing group
the contralateral pressing group
and the distal pressing group showed an increased mechanical pain threshold and decreased soft tissue tension
a lower spontaneous potential frequency amplitude
and lower SP and CGRP levels (
P
<
0.05)
with the local pressing group showing the greatest improvement (
P
<
0.05) and significant recovery on morphological analysis. The contralateral pressing group showed a better improvement in EMG
CGRP
and SP than the distal pressing group (
P
<
0.05).
Conclusion
2
Local pressing
contralateral limb pressing
and distal pressing at KI3 can relieve the pain of MTrPs
reduce soft tissue tension
and decrease spontaneous electrical activity
possibly by reducing the expression of SP and CGRP. Local pressing on MTrPs showed the best efficacy
followed by contralateral pressing and then distal pressing at KI3.
激痛点局部按法对侧按法远端按法太溪大鼠
myofascial trigger pointslocal pressingcontralateral pressingdistal pressingKI3rats
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