1.北京中医药大学东直门医院 北京 100700
2.首都医科大学附属北京安定医院
陈琛,女,在读博士生
# 邹忆怀,男,博士,教授,主任医师,博士生导师,主要研究方向:中医药防治神经系统疾病及脑功能重塑,E-mail:zouyihuai2004@163.com
纸质出版日期:2023-08-30,
收稿日期:2022-11-23网络出版日期: 2023,
移动端阅览
陈琛, 邹忆怀, 宁艳哲, 等. 从毒损络脉论治运动神经元病[J]. 北京中医药大学学报, 2023,46(8):1150-1155.
CHEN Chen, ZOU Yihuai, NING Yanzhe, et al. Discussion on treatment of motor neuron disease by toxins damaging collaterals[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(8):1150-1155.
陈琛, 邹忆怀, 宁艳哲, 等. 从毒损络脉论治运动神经元病[J]. 北京中医药大学学报, 2023,46(8):1150-1155. DOI: 10.3969/j.issn.1006-2157.2023.08.013.
CHEN Chen, ZOU Yihuai, NING Yanzhe, et al. Discussion on treatment of motor neuron disease by toxins damaging collaterals[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(8):1150-1155. DOI: 10.3969/j.issn.1006-2157.2023.08.013.
运动神经元病可归属于中医学“痿痉并病”范畴,属临床难治性疾病,对于该病的辨证治疗诸多学者各有创见,但并无明确的共识。毒损络脉从王永炎院士提出的“毒损脑络”学说发展而来,诸邪蕴积成毒,毒邪损络,扩散蔓延,直接损伤脏腑形质,形质败坏而使病情迅速恶化。结合中医学理论及现代研究,本文认为毒损络脉的病理改变与运动神经元病病变的隐匿性、广泛性、难治性等特点相吻合,提出毒损络脉可能是运动神经元病发生发展的核心病机,即外感、内伤之毒邪胶结壅塞于髓络,毒损髓络,气血失调,代谢失衡,继而脑髓与脊髓损伤则发为运动神经元病。进而由毒损络脉延伸出气虚、内风相关病机,气虚与毒损络脉互为影响导致患者病情日趋加重,运动神经元病筋脉之风象可能由毒损络脉引动,由此提出解毒通络以祛邪、补气育阴以固本的治疗原则,强调益气解毒、育阴熄风,兼以通络的治法,以期拓宽中医药治疗运动神经元病的思路,进一步提高临床疗效。
Motor neuron disease (MND)
a clinical refractory disease
can be classified as "a disease of flaccidity and spasticity" in traditional Chinese medicine (TCM). Many doctors have their own ideas regarding the treatment of syndrome differentiation
but there is no clear consensus. The concept of toxins damaging collaterals was developed from the theory of "toxins damaging brain collaterals" put forward by academicia Wang Yongyan
which marks the pathological process of toxicity accumulation and toxicity to collaterals
causing the spread of toxicity
directly damaging the shape and quality of the zang-fu organs and resulting in rapid deterioration of the disease. Combined with the theory of TCM and modern research
the pathological changes of toxins damaging collaterals are consistent with the characteristics of occult
extensive
and intractable lesions of MND. It is suggested that toxins damaging collaterals may be the core pathogenesis of the occurrence and development of MND
namely
the accumulation of toxins from external contraction and internal damage in the medullary collaterals leads to damage to the medullary collaterals
imbalance of qi and blood
metabolic imbalance
and subsequent brain and spinal cord injuries
leading to MND. Moreover
qi deficiency and internal wind-related pathogenesis are extended from toxins damaging collaterals. Qi deficiency and toxins damaging collaterals influence each other
leading to the worsening of disease. Wind images of MND muscles may be induced by toxins damaging collaterals. Therefore
the treatment principle of detoxifying and regulating collaterals to remove evil
replenishing qi
and nourishing yin to solidify the root is put forward
emphasizing supplementing qi and detoxifying
nourishing yin and dispelling wind
and regulating collaterals
in order to expand the options for MND treatment and further improve the clinical effect.
运动神经元病毒损络脉气虚内风益气解毒育阴熄风通络
motor neuron diseasetoxins damaging collateralsqi deficiencyinternal windsupplementing qi and detoxifyingnourishing yin and dispelling windregulating collaterals
LA FOSTER, MK SALAJEGHEH. Motor Neuron Disease: Pathophysiology, Diagnosis, and Management [J]. Am J Med, 2019, 132(1): 32-37.
XJ XU, DD SHEN, YN GAO, et al. A perspective on therapies for amyotrophic lateral sclerosis: can disease progression be curbed? [J/OL]. Transl Neurodegener, 2021, 10(1): 29[2022-08-15].https://translation-alneurodegeneration.biomedcentral.com/articles/10.1186/s40035-021-00250-5.
尤怡.金匮要略心典[M]. 杨旭杰,点校. 北京:人民军医出版社,2009:33.
刘宁,赵进喜,贾海忠,等. 毒邪致病,急危疑难;从毒论治,重在审因[J]. 环球中医药,2021, 14(12): 2166-2169.
难经[M].于莉英,点校. 南京:江苏科学技术出版社,2008:44.
张锦,张允岭,郭蓉娟,等. 从“毒损脑络”到“毒损络脉”的理论探讨[J]. 北京中医药,2013, 32(7): 483-486.
李澎涛,王永炎. 毒损络脉病机的理论内涵及其应用[J]. 中医杂志,2011, 52(23): 1981-1984.
陈小敏,张健,丁砚兵,等. 从络虚毒损探讨症状性颅内动脉粥样硬化性狭窄因机治法[J]. 北京中医药大学学报,2022, 45(2): 135-139.
苏鑫,陈成顺,许亚梅. 基于“毒损髓络”理论辨治急性白血病经验[J]. 北京中医药,2020, 39(1): 44-47.
冯广树,马斌,冯广娟,等. 浅论“毒”邪为肌萎缩侧索硬化症发病的重要病因及其辨治思路[J]. 环球中医药,2020, 13(2): 278-281.
杨清波,贺鹏飞,马斌,等. 从伏毒角度探讨肌萎缩侧索硬化[J]. 现代中医临床,2022, 29(5): 55-59.
TE RYAN, ML ERICKSON, A VERMA, et al. Skeletal muscle oxidative capacity in amyotrophic lateral sclerosis[J]. Muscle Nerve, 2014, 50(5): 767-774.
AR MEHTA, JM GREGORY, O DANDO, et al. Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis [J]. Acta Neuropathol, 2021, 141(2): 257-279.
B DEBYE, L SCHMÜLLING, LP ZHOU, et al. Neurodegeneration and NLRP3 inflammasome expression in the anterior thalamus of SOD1(G93A) ALS mice [J]. Brain Pathol, 2018, 28(1): 14-27.
P ITALIANI, C CARLESI, P GIUNGATO, et al. Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis[J/OL]. J Neuroinflammation, 2014, 11: 94[2022-08-12]. https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-11-94.
H KADHIM, P DELTENRE, JJ MARTIN, et al. In-situ expression of Interleukin-18 and associated mediators in the human brain of sALS patients: Hypothesis for a role for immune-inflammatory mechanisms[J]. Med Hypotheses, 2016, 86: 14-17.
胡慎柔. 慎柔五书[M]. 郑金生,整理. 北京:人民卫生出版社,2006:90.
冯瑞华,马斌,冯广树,等. 运动神经元病证候要素分布及组合规律探析[J]. 环球中医药,2020, 13(12): 2036-2041.
孙思邈. 千金方[M].刘清国,校注. 北京:中国中医药出版社,1998:197.
张磊,陈腾飞,郭玉红. 刘清泉教授通络散风法辨治运动神经元病经验[J]. 环球中医药,2017, 10(11): 1388-1390.
汪双双,杨晓军,邓铁涛,等. 邓铁涛教授治疗肌萎缩侧索硬化症经验整理[J]. 广州中医药大学学报,2010, 27(3): 310-312.
D SPROVIERO, S LA SALVIA, M GIANNINI, et al. Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients[J/OL]. Front Neurosci, 2018, 12: 487[2022-08-15]. https://www.frontiersin.org/articles/10.3389/fnins.2018.00487/full.
L LE GALL, WJ DUDDY, C MARTINAT, et al. Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles[J]. J Cachexia Sarcopenia Muscle, 2022, 13(2): 1385-1402.
俞根初. 重订通俗伤寒论[M].徐荣斋,重订. 北京:中国中医药出版社,2011:103.
唐宗海. 血证论[M].魏武英,曹健生,点校. 北京:人民卫生出版社,1990:7.
邱丙庆. 论毒邪[J]. 中医药学报,2013, 41(4): 7-9.
旁安时. 伤寒总病论[M].王鹏,王振国,整理. 北京:人民卫生出版社,2007:3.
李东垣. 脾胃论[M].文魁,丁国华,整理. 北京:人民卫生出版社,2005:4.
邓伟. 周仲瑛“难病多毒”学术思想初探[J]. 四川中医,2009, 27(3): 3-4.
常富业,王永炎. 浅谈津络学说[J]. 北京中医药大学学报,2022, 45(1): 11-14.
叶天士. 临证指南医案[M]. 华岫云,编订. 北京:华夏出版社,1995:340.
0
浏览量
11
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构