基于肠道菌群-脂代谢探讨代谢综合征痰证的微观辨证
Discussion on the microscopic syndrome differentiation of phlegm syndrome in metabolic syndrome based on gut microbiota associated with lipid metabolism
- 北京中医药大学学报 2023年46卷第11期 页码：1517-1522
- 作者机构：
1.福建中医药大学中医学院 福州 350122
2.福建省2011中医健康管理协同创新中心
3.福建省中医健康状态辨识重点实验室
4.福建中医药大学附属人民医院内分泌科
- 作者简介：
夏淑洁，女，博士，讲师
# 李灿东，男，博士，教授，博士生导师，主要研究方向：中医诊断与健康管理，E-mail：fjzylcd@126.com
- 基金信息：国家自然科学基金项目(82204977;U22A20376);广东省中医药信息化重点实验室开放项目(2022601);福建中医药大学青年科技创新培育项目(XQC2023002)
DOI：10.3969/j.issn.1006-2157.2023.11.006
中图分类号： R259.89纸质出版日期：2023-11-30，
网络出版日期：2023-09-08，
收稿日期：2023-05-17，
- 稿件说明：
移动端阅览
夏淑洁, 米丽芬, 沈姗怡, 等. 基于肠道菌群-脂代谢探讨代谢综合征痰证的微观辨证[J]. 北京中医药大学学报, 2023,46(11):1517-1522.
XIA Shujie, MI Lifen, SHEN Shanyi, et al. Discussion on the microscopic syndrome differentiation of phlegm syndrome in metabolic syndrome based on gut microbiota associated with lipid metabolism[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(11):1517-1522.
夏淑洁, 米丽芬, 沈姗怡, 等. 基于肠道菌群-脂代谢探讨代谢综合征痰证的微观辨证[J]. 北京中医药大学学报, 2023,46(11):1517-1522. DOI： 10.3969/j.issn.1006-2157.2023.11.006.
XIA Shujie, MI Lifen, SHEN Shanyi, et al. Discussion on the microscopic syndrome differentiation of phlegm syndrome in metabolic syndrome based on gut microbiota associated with lipid metabolism[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(11):1517-1522. DOI： 10.3969/j.issn.1006-2157.2023.11.006.
摘要
代谢综合征是以肥胖、高血糖、高血压、血脂异常等聚集发病为特点的代谢紊乱症候群。其中，向心性肥胖是代谢综合征重要的始发因素与临床表现，而肠道菌群失调会诱发代谢性炎症及胰岛素抵抗，其介导的脂代谢紊乱在代谢综合征的发生、发展中起到重要作用。痰为代谢综合征的重要病理因素，并与肠道菌群失调、脂代谢紊乱相关。本文从“肠道菌群-脂代谢”角度系统梳理代谢综合征痰证的病理机制，并提出代谢综合征痰证与肠道菌群介导的脂代谢紊乱关系密切，将两者联合分析并结合机器学习等方法可从整体上探索代谢综合征痰证的生物学基础，并对其进行微观辨证，可为代谢综合征痰证的科学内涵和干预靶点研究提供理论参考依据。
Abstract
Metabolic syndrome is a cluster of metabolic disorders associated with obesity
hyperglycemia
hypertension
and dyslipidemia. Central obesity is an important initiating factor and clinical manifestation of metabolic syndrome
while an imbalance in the intestinal flora can induce metabolic inflammation and insulin resistance. Lipid metabolism disorder also plays an important role in the occurrence and development of metabolic syndrome. Phlegm is an important pathological factor of metabolic syndrome that correlates with the intestinal microbiota and lipid metabolism disorders. Therefore
this paper systematically investigated the pathological mechanisms underlying metabolic syndrome with phlegm syndrome from the perspective of "intestinal microbiota-lipid metabolism"
and proposed that metabolic syndrome with phlegm syndrome is closely related to lipid metabolism disorder mediated by intestinal microbiota. Combining the two diseases and machine learning furthers our understanding of the biological basis of metabolic syndrome with phlegm syndrome and provides a mechanism for microscopically differentiating the syndromes
acting as a theoretical reference for scientific research into disease prognoses and treatment targets.
关键词
代谢综合征痰证微观辨证肠道菌群脂代谢
Keywords
metabolic syndromephlegm syndromemicroscopic syndrome differentiationgut microbiotalipid metabolism
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