1.北京中医药大学 北京 100029
2.中日友好医院
庄明月,女,在读硕士生
# 杨顶权,男,主任医师,教授,博士生导师,主要研究方向:中西医结合治疗毛发、瘢痕疾病,E-mail:ydqlx@163.com
纸质出版日期:2023-11-30,
网络出版日期:2023-07-11,
收稿日期:2022-11-25,
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庄明月, 刘青武, 田子园, 等. 基于因子-聚类分析的1 000例男性雄激素性秃发患者中医证候研究[J]. 北京中医药大学学报, 2023,46(11):1574-1581.
ZHUANG Mingyue, LIU Qingwu, TIAN Ziyuan, et al. Study on the traditional Chinese medicine syndromes of 1, 000 male patients with androgenetic alopecia based on factor-cluster analysis[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(11):1574-1581.
庄明月, 刘青武, 田子园, 等. 基于因子-聚类分析的1 000例男性雄激素性秃发患者中医证候研究[J]. 北京中医药大学学报, 2023,46(11):1574-1581. DOI: 10.3969/j.issn.1006-2157.2023.11.012.
ZHUANG Mingyue, LIU Qingwu, TIAN Ziyuan, et al. Study on the traditional Chinese medicine syndromes of 1, 000 male patients with androgenetic alopecia based on factor-cluster analysis[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(11):1574-1581. DOI: 10.3969/j.issn.1006-2157.2023.11.012.
目的
2
探究男性雄激素性秃发患者的中医证候分布特点。
方法
2
回顾性收集2020年1—12月中日友好医院毛发医学中心收治的1 000例男性雄激素性秃发患者的临床资料。采用自行设计的中医症状调查表收集四诊信息,使用Excel软件和SPSS 26.0软件进行描述性频数分析、因子-聚类分析和卡方检验,归纳出主要中医证候及症状分布规律。
结果
2
1 000例男性雄激素性秃发患者中,按频数统计,排在前5位的症状依次为:头皮出油(94.6%)、头皮脱屑(73.0%)、头皮瘙痒(71.2%)、情志抑郁(67.5%)、倦怠乏力(66.3%)。根据因子-聚类分析得出的4种中医证候依次为湿热内蕴证(34.6%)、肝郁脾虚证(28.7%)、血热风燥证(22.2%)、肝肾亏虚证(14.5%)。20~
<
30岁患者以湿热内蕴证为主,30~
<
40岁患者以肝郁脾虚证为主,40~
<
50岁患者以湿热内蕴证为主。30~
<
40岁患者的中医证候分布比较差异有统计学意义(
P
<
0.05)。
结论
2
男性雄激素性秃发以湿热内蕴证、肝郁脾虚证为主,不同年龄段的证候分布存在差异。因子-聚类分析结果结合临床经验探讨中医证候,对男性雄激素性秃发的临床辨证论治具有参考性。
Objective
2
To study the characteristics of traditional Chinese medicine (TCM) syndromes in male patients with androgenetic alopecia (AGA).
Methods
2
The clinical data of 1
000 male patients with AGA admitted to the Hair Medicine Center of China-Japan Friendship Hospital from January 2020 to December 2020 were retrospectively collected. A self-designed TCM symptom questionnaire was used to collect clinical information of the four examinations. Descriptive frequency analysis
factor-cluster analysis
and Chi-square test were performed using Excel and SPSS 26.0 software. The clinical data were combined to summarize the main TCM syndromes and symptoms.
Results
2
The top five symptoms ranked by frequency were scalp oil (94.6%)
scalp scurf(73.0%)
scalp pruritus(71.2%)
depression(67.5%)
and fatigue (66.3%). Four TCM syndromes were derived using factor-cluster analysis: syndrome of internal retention of dampness-heat (34.6%)
syndrome of liver depression and spleen deficiency(28.7%)
syndrome of blood heat and wind-dryness(22.2%)
and syndrome of liver-kidney deficiency (14.5%). Men aged 20 to
<
30 years were mainly syndrome of internal retention of dampness-heat
those aged 30 to
<
40 years were mainly syndrome of liver depression and spleen deficiency
and those aged 40 to
<
50 years were mainly syndrome of internal retention of dampness-heat. There was a significant difference in the distribution of TCM syndromes in patients aged 30 to
<
40 years (
P
<
0.05).
Conclusion
2
Male AGA syndromes are mainly syndrome of internal retention of dampness-heat and syndrome of liver depression and spleen deficiency
and the distribution of syndromes differs across age groups. It is feasible to evaluate TCM syndromes with factor-cluster analysis combined with experts’ experiences for the clinical syndrome differentiation and treatment of male AGA.
雄激素性秃发中医证候因子-聚类分析
androgenetic alopeciatraditional Chinese medicinesyndromefactor-cluster analysis
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